National Changhua University of Education Institutional Repository : Item 987654321/10105
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题名: Mechanism of Chain Termination in Lipid Peroxidation by Carotenes: A Theoretical Study
作者: Guo, Jian-Jhih;Hu, Ching-Han
贡献者: 化學系
日期: 2010-12
上传时间: 2012-05-03T06:18:31Z
出版者: American Chemical Society
摘要: The reaction mechanism of carotenes (CARs) in chain termination against lipid peroxidation was studied using density functional theory. In the presence of peroxide (ROO·), the reaction barrier for its addition to CAR to form ROO−CAR· is smaller than those for its hydrogen abstractions from CAR and linoleic acid (LAH), respectively. In contrast, the reaction barriers for the O2 additions of the carbon-centered radicals are ordered as ROO−CAR· > CAR(−H)· > LA·. Thus, the chain-termination function of CAR is best demonstrated by trapping the addition radical and suppressing O2 addition. For either the ROO−CAR· or CAR(−H)· radicals, β-carotene has noticeably higher O2 addition barriers than those of their lycopene counterparts. The reaction barrier for the rearrangement of ROO−CAR· into RO· + epoxide is much smaller than that for the formation of cyclic ether and is comparable to that of O2 addition. Since RO· has a stronger tendency toward hydrogen abstraction than ROO·, the rearrangement of the addition adduct has to be recognized as an important factor while evaluating the chain-termination potency of a molecule. The overall reaction energy profile reveals that the protective function of CAR is mostly exhibited via formation of the addition adduct. Comparatively, β-carotene is a more potent antiradical agent than lycopene against peroxide-initiated lipid peroxidation.
關聯: J. Phys. Chem. B, 114(50): 16948-16958
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