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题名: Hb Siriraj: a G→A Substitution at Codon 7 of the Beta-globin Chain Creates an MboII Cutting Site
作者: Chang, J. G.;Yang, T. Y.;Perng, L. I.;Wang, Nancy M.;Peng, C. T.;Tsai, C. H.
贡献者: 生物技術研究所
日期: 1999-05
上传时间: 2012-06-06T02:03:15Z
摘要: Nesidioblastosis as the cause of hyperinsulinaemic hypoglycaemia in an adult is rare. We report here an additional case of nesidioblastosis, which resulted in fatal hyperinsulinaemic hypoglycaemia in a 72-year-old woman with an underlying myelodysplastic syndrome. The diagnosis of nesidioblastosis was established only after post-mortem examination with a careful exclusion of minute insulinoma. To our surprise, the renal pathology disclosed typical diabetic nodular glomerulosclerosis in the same patient who had no previous history of diabetes mellitus (DM). Nesidioblastosis has been reported to cause 'reversal' of Type 1 DM and insulinoma causing 'reversal' of Type 2 disease. We therefore hypothesize that our patient might have had an undiagnosed DM in the past, which resulted in the typical diabetic nodular glomerulosclerosis. The nesidioblastosis caused a 'reversal' of DM and even the ultimate development of hyperinsulinaemic hypoglycaemia.
關聯: Hemoglobin, 23(2): 197-199
显示于类别:[生物技術研究所] 期刊論文


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