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Title: Molecular Analysis of Duffy, Yt and Colton Blood Groups in Taiwanese, Filipinos and Thais
利用分子診斷來分析Duffy, Yt及Colton血型基因型在台、菲、泰三種族的分佈
Authors: Peng, Ching-Tien;Tsai, Chang-Hai;Lee, Hsien-Hsiung;Lin, Chiao-Lin;Wang, Nancy M.;Chang, Jan-Gowth
Contributors: 生物技術研究所
Keywords: Duffy;Colton;Yt;Blood groups;DNA typing
Date: 2000-02
Issue Date: 2012-06-06T02:04:02Z
Publisher: 高雄醫學大學
Abstract: We used a polymerase chain reaction-restriction fragment length polymorphism (PCR.RFLP) method for DNA.based typing of Duffy, Yt and Colton blood groups in Taiwanese, Filipinos and Thais. A total of 200 Taiwanese, 115 Filipinos and 105 Thais were studied. In the Duffy blood group in Taiwanese, 180 cases (90%) were homozygote of Fya, 18 cases (9%) were double heterozygote of Fya and Fyb, and 2 cases (1%) were homozygote 'of Fyb. In Filipinos, 98 cases (85.2%) were homozygote of Fya, 16 cases (14.0%) were double heterozygote ofFya and Fyb and 1 case (0.8%) was homozygote of Fyb. In Thais, 87 cases (82.9%) were homozygote of Fya, 18 cases (17.1%) were double heterozygote of Fya and Fyb, and no case of Fyb was found. These results correlate well with serological phenotype. For the Yt blood group, only YTI was found in Taiwanese. Among Filipinos, 114/115 (99. 1%) was YTI/l and 1/115 (0.9%) was YTI/2. In Thais, 103/105 (98.1%) was YTI/ 1 and 2/105 (1.9%) was YTI/2. For the Colton blood group, the results showed that there was only COB allele in these three populations. Our results provide the first data of the Yt and Colton blood groups in these three populations.
Relation: The Kaohsiung Journal of Medical Sciences, 16(2): 63-67
Appears in Collections:[生物技術研究所] 期刊論文

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