National Changhua University of Education Institutional Repository : Item 987654321/11508
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 6507/11669
造訪人次 : 30154865      線上人數 : 858
RC Version 3.2 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 進階搜尋

請使用永久網址來引用或連結此文件: http://ir.ncue.edu.tw/ir/handle/987654321/11508

題名: No Evidence of Correlation between Mutation at Codon 531 of Src and the Risk of Colon Cancer in Chinese
作者: Wang, Nancy M.;Yeh, Kun-Tu;Tsai, Chan-Hai;Chen, Shu-Jung;Chang, Jan-Gowth
貢獻者: 生物技術研究所
關鍵詞: Src;Colon cancer;Polymerase chain reaction;Proto-oncogene protein pp60c-src;Chinese
日期: 2000-03
上傳時間: 2012-06-06T02:04:18Z
出版者: Elsevier
摘要: The protein tyrosine kinase activity of c-src proto-oncogene product, pp60c-src, is elevated in a number of human cancers, including colon cancer. Phosphorylation of human pp60c-src carboxy-terminal tyrosine 530 suppresses its kinase activity. A recent report suggested that the risk of colon cancer is higher for those who carry a C→T transition mutation on codon 531 (Gln-531→Amber-531) of src gene. This mutation caused a prematured translation termination and up-regulated the kinase activity. To examine whether this mutation could be a risk factor for colon carcinoma in the Chinese population, we used the same PCR-based assay to analyze src genotypes of 131 colon cancers and other various types of carcinoma. No mutation was detected in all specimens that were screened in this study. Thus, mutation at Gln-531 of src gene does not seem to be involved in the development of colon cancer in Chinese ethnicity.
關聯: Cancer Letters, 150(2): 201-204
顯示於類別:[生物技術研究所] 期刊論文

文件中的檔案:

檔案 大小格式瀏覽次數
index.html0KbHTML636檢視/開啟


在NCUEIR中所有的資料項目都受到原著作權保護.

 

DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋