National Changhua University of Education Institutional Repository : Item 987654321/11509
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题名: G Protein β3 Subunit Variant and Essential Hypertension in Taiwan - a case-control Study
作者: Tsai, Cheng-Ho;Yeh, Hung-I;Chou, Yusan;Liu, Hsin-Fu;Yang, Tzu-Yao;Wang, Jyh-Chwan;Wang, Nancy M.;Chang, Jan-Gowth
贡献者: 生物技術研究所
关键词: Hypertension;G-protein b3 subunit;Gene
日期: 2000-04
上传时间: 2012-06-06T02:04:19Z
出版者: Elsevier
摘要: Recent studies have shown that a C825T polymorphism of the gene encoding the G protein beta3 subunit contributes to the genesis of essential hypertension. However, the link between the gene and blood pressure is not consistently found in different populations. The aim of the present study is to investigate this issue in Taiwan. We analyzed the allelic status in 302 hypertensive (age, 60+/-11 years; male/female, 136/166) and 199 normotensive subjects (62+/-15 years; male/female, 90/109). Our result showed that the T allelic was more frequently seen in the hypertensive group than the normotensive, but the difference did not reach statistic significance (56.5 vs. 54.3%, P>0.1). Subsequent analysis demonstrated a similar trend in the female (58.7 vs. 53.7%, P>0.1) but a reverse trend in the male (53.7 vs. 55%, P>0.1). Another finding was that the T allele frequency in all the groups was over 50%, markedly higher than those reported in whites. In conclusion, the observation suggests that the polymorphism in the G protein gene is not likely to play an important role in the manifestation of high blood pressure in Taiwan.
關聯: Int. J. Cardiol., 73(2): 191-195
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