National Changhua University of Education Institutional Repository : Item 987654321/11510
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 6507/11669
造訪人次 : 29914237      線上人數 : 297
RC Version 3.2 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 進階搜尋

請使用永久網址來引用或連結此文件: http://ir.ncue.edu.tw/ir/handle/987654321/11510

題名: Aberrant Transcripts of FHIT, TSG101 and PTEN/MMAC1 Genes in Normal Peripheral Mononuclear Cells
作者: Wang, Nancy M.;Chang, J. G.;Liu, T. C.;Lin, S. F.;Peng, C. T.;Tsai, F. J.;Tsai, C. H.
貢獻者: 生物技術研究所
日期: 2000-06
上傳時間: 2012-06-06T02:04:20Z
出版者: Spandidos Publications Ltd
摘要: Aberrant transcripts of FHIT and TSG101 using nested RT-PCR were reported in many human tumours. The role of these aberrant transcripts in tumourigenesis is not clear. We, therefore, analyzed the aberrant transcripts of FHIT, TSG101 and PTEN/MMAC1 in peripheral mononuclear cells of normal individuals using nested RT-PCR to explore the role of these genes in cancer development. The results showed that there are at least five types of aberrant transcripts: type I is the deletion at junction located in-between normal exon and intron; type II has deletion of some bases and subsequent insertion of several bases in the deletion area; type III accommodates splicing donor or acceptor site-like sequence; type IV has homologous sequences near the deleted junction; and type V comprises the homologous sequences at the deletion junction. A normal healthy person can have more than one aberrant transcripts of FHIT, TSG101 and PTEN/MMAC1 genes. The size and the number of the transcripts vary and the diversity is unconstrained. It is not depended on the time, condition of the reaction, or the isolation method. From these results, we suggested that the aberrant transcripts of FHIT, TSG101 and PTEN/MMAC1 genes may be the imperfect products of splicesome which occur one in every thousands, ten thousands or more. As a result, these data implied no direct association between the aberrant transcripts and tumourigenesis.
關聯: Int. J. Oncol., 16(1): 75-80
顯示於類別:[生物技術研究所] 期刊論文

文件中的檔案:

檔案 大小格式瀏覽次數
2020700310028.pdf8KbAdobe PDF772檢視/開啟


在NCUEIR中所有的資料項目都受到原著作權保護.

 

DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋