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题名: Mutation Analysis of the BCL 10 Gene in Hepatocellular Carcinoma
肝癌之Bcl 10基因的突變分析
作者: Yeh, Kun-Tu;Wang, Nancy M.;Lee, Hsien-Hsiung;Chang, Jan-Gowth
贡献者: 生物技術研究所
关键词: Bcl 10;Mutation analysis;Hepatocellular carcinoma
日期: 2000-07
上传时间: 2012-06-06T02:04:33Z
出版者: 高雄醫學大學
摘要: The Bcl 10 gene was recently discovered to be involved in the pathogenesis of lymphoma of mucosa-associated lymphoid tissue and several types of tumorous cell lines. We examined the mutation of Bcl 10 gene in 31 hepatocellular carcinomas along with their corresponding non-tumorous tissues by single strand conformation polymorphism (SSCP) and direct sequencing. The results showed that 11.3 % chromosomes had codon 5 GCA to TCA mutation, 4.8% chromo. somes had codon 8 CTC to CTG mutation, and 12.9% chromosomes had codon 213 GGA to GAA mutation. These mutations were found not only in the hepatoma tissues but also in paired non-cancerous tissues and the normal population. We suggest that these three changes are polymorphisms, and there is no relation ship with the development of hepatocellular carcinoma.
Bcl 10基因最近發現與黏膜淋巴組織形成的淋巴癌及其它癌細胞株的變有關。我們檢查了３１個肝癌組織和其鄰近的非癌組織中Bcl 10基因的突變，結果顯示，在肝癌組織中，11.3％的chromosomes有codon 5 GCA→TCA 突變，4.8%的chromosomes 有 codon 8 CTC→CTG突變，及12.9% 的 chromomsomes有codon 213GGA→GAA突變；而這些突變在非肝癌組統及正人中也同樣的變化。我們認為這三種突變與肝癌的形成無關。
關聯: The Kaohsiung Journal of Medical Sciences, 16(7): 332-338
显示于类别:[生物技術研究所] 期刊論文

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