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|Title: ||Two-photon Fluorescence Correlation Spectroscopy through a Dual-Clad Optical Fiber|
|Authors: ||Chang, Yu-Chung;Ye, Jing-Yong;Thomas, Thommey;Chen, Yi;Baker, James R.;Norris, Theodore B.|
|Issue Date: ||2012-07-03T01:48:29Z
|Publisher: ||Optical Society of America|
|Abstract: ||We report on the utilization of a dual-clad optical fiber for twophoton excited fluorescence correlation spectroscopy (FCS). High excitation|
efficiency is obtained by sending prechirped ultrafast pulses through the single-mode core of the fiber, while the fluorescence collection efficiency is enhanced because of the larger numerical aperture of the inner cladding. We show that the utilization of a dual-clad fiber is critical for ultrasensitive twophoton fluorescence detection. Our system has the ability to detect fluorescent nanospheres as small as 12 nm in radius. Quantum dots of radius 7 nm are also measured and show excellent signal to noise ratio. The particle sizes obtained from the fiber FCS system were confirmed by measurements using a commercial dynamic light scattering (DLS) system.
|Relation: ||Optics Express, 16(17): 12640-12649|
|Appears in Collections:||[電機工程學系] 期刊論文|
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