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题名: Two-photon Fluorescence Correlation Spectroscopy through a Dual-Clad Optical Fiber
作者: Chang, Yu-Chung;Ye, Jing-Yong;Thomas, Thommey;Chen, Yi;Baker, James R.;Norris, Theodore B.
贡献者: 電機工程學系
日期: 2008
上传时间: 2012-07-03T01:48:29Z
出版者: Optical Society of America
摘要: We report on the utilization of a dual-clad optical fiber for twophoton excited fluorescence correlation spectroscopy (FCS). High excitation
efficiency is obtained by sending prechirped ultrafast pulses through the single-mode core of the fiber, while the fluorescence collection efficiency is enhanced because of the larger numerical aperture of the inner cladding. We show that the utilization of a dual-clad fiber is critical for ultrasensitive twophoton fluorescence detection. Our system has the ability to detect fluorescent nanospheres as small as 12 nm in radius. Quantum dots of radius 7 nm are also measured and show excellent signal to noise ratio. The particle sizes obtained from the fiber FCS system were confirmed by measurements using a commercial dynamic light scattering (DLS) system.
關聯: Optics Express, 16(17): 12640-12649
显示于类别:[電機工程學系] 期刊論文


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