National Changhua University of Education Institutional Repository : Item 987654321/11997
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题名: Arginine Vasopressin Produces Inhibition upon Respiration without Pressor Effect in the Rat
作者: Chuang, Ching-Wen;Cheng, Meng‐Tzu;Lin, Jin-Tun;Hsien, Hsin-Yun;Hung, Hzi-Yu;Hwang, Ji-Chuu
贡献者: 生物學系
关键词: Arginine vasopressin;AVP V1A receptor antagonist;Ventrolateral medulla;Phrenic nerve activity;rat
日期: 2003-06
上传时间: 2012-07-03T02:45:06Z
出版者: The Chinese Physiological Society & Airiti Press
摘要: The purpose of the current study was to examine where arginine vasopressin (AVP) inhibits respiration by direct action on the areas of the ventrolateral medulla (VLM) in the rat. The animal was anesthetized by urethane (1.2 g/kg, i.p.), paralyzed with gallamine triethiodide, and artificially ventilated. Catheterization of the femoral artery and vein, and bilateral vagotomy were performed. The rat was then placed upon a stereotaxic instrument in a prone position. The phrenic nerve was separated and cut peripherally. Phrenic nerve activity (PNA) was monitored at normocapnia and hypercapnia in hyperoxia. Microinjection of AVP into various subregions of the VLM was then performed. In response to AVP microinjection, a transient period of apnea and then a significant decrease in PNA amplitude were observed. Arterial blood pressure was unchanged. This inhibition of PNA with AVP treatment was site-specific, attenuated by raising CO2 concentration, and totally abolished by pretreatment with AVP V1A receptor antagonist. Data of the present study indicate that endogenous resource of AVP may produce an inhibitory effect upon respiration via AVP receptors presented on neurons within the VLM.
關聯: The Chinese Journal of Physiology, 46(2): 71-78
显示于类别:[生物學系] 期刊論文

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