National Changhua University of Education Institutional Repository : Item 987654321/11998
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题名: Cardiopulmonary Response to Vasopressin-Induced Activation on V1A Receptors in the Lateral Ventrolateral Medulla in the Rat
作者: Cheng, Meng‐Tzu;ChuangChing-Wen;Lin, Jin-Tun;Hwang, Ji-Chuu
贡献者: 生物學系
关键词: Arginine vasopressin;AVP V1A-receptor antagonist;Ventrolateral medulla;Phrenic nerve activity;Hypercapnia;Blood pressure;rat
日期: 2004-03
上传时间: 2012-07-03T02:45:09Z
出版者: The Chinese Physiological Society & Airiti Press
摘要: The aim of the study was to examine whether or not arginine vasopressin (AVP) might modulate
cardiopulmonary functions by acting on the lateral area of the ventrolateral medulla (VLM) in the rat.
The rat was anesthetized, bilaterally vagotomized, paralyzed, ventilated, and then placed on a stereotaxic
instrument in a prone position. Activity of the phrenic nerve (PNA) was monitored at normocapnia and
hypercapnia in hyperoxia. Microinjection of AVP into the lateral region of the VLM resulted in a brief
apnea followed by a significant decrease in PNA amplitude and a concomitant significant increase in
blood pressure. The inhibition of PNA with AVP treatment could be partly attenuated by hypercapnia
but not by phentolamine. Both inhibition of PNA and pressor response with AVP microinjection into the
lateral VLM were totally abolished after pretreatment with AVP V1A receptor antagonist. These results
suggest that a vasopressinergic pathway projects to the lateral VLM and modulates cardiopulmonary
functions via AVP V1A receptors on neurons within the lateral VLM.
關聯: The Chinese Journal of Physiology, 47(1): 31-42
显示于类别:[生物學系] 期刊論文

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