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Title: Adiponectin, Inflammation, and the Expression of the Metabolic Syndrome in Obese Individuals: The Impact of Rapid Weight Loss through Caloric Restriction
Authors: Antonios M. Xydakis, Christopher C. Case, Peter H. Jones, Ron, C. Hoogeveen, Liu, Mine-Yine;E. O’Brian Smith, Kathie Nelson, and Christie M. Ballantyne
Contributors: 化學系
Date: 2004-06
Issue Date: 2012-07-03T03:29:34Z
Publisher: The Endocrine Society
Abstract: Severe obesity increases the prevalence of the metabolic syndrome, and moderate acute weight loss with a very low-calorie diet in obese subjects with the metabolic syndrome leads to significant metabolic benefits. Adiponectin has been implicated in both the pathogenesis of obesity-related insulin resistance and increased inflammation. We analyzed the relationship of the adipocyte-derived hormone adiponectin with indices of inflammation, adiposity, and insulin resistance in obese subjects with (MS+, n = 40) and without (MS−, n = 40) the metabolic syndrome and examined the acute effects of rapid weight loss. MS+ subjects had significantly lower adiponectin (7.6 ± 0.6 vs. 10.4 ± 0.6 μg/ml; P = 0.003) and significantly higher TNF-α (3.3 ± 0.2 vs. 2.8 ± 0.3 pg/ml; P = 0.004) levels compared with MS− subjects matched for age and body mass index. Plasma adiponectin and TNF-α levels were inversely related to the number of metabolic syndrome factors in a stepwise manner. After 4–6 wk of weight loss, there was marked improvement in glucose, insulin, leptin, and triglycerides, whereas adiponectin and TNF-α concentrations did not change. Thus, increases in plasma levels of adiponectin or reductions in TNF-α are not required for marked improvements in glucose/insulin and lipid metabolism with acute weight loss.
Relation: The Journal of Clinical Endocrinology & Metabolism, 89(6): 2697-2703
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