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题名: Acquired ADAMTS-13 Deficiency in Pediatric Patients with Severe Sepsis
作者: Nguyen, Trung C.;Liu, Anne;Liu, Li;Ball, Chalmette;Choi, Hiuwan;May, William S.;Aboulfatova, Khatira;Bergeron, Angela L.;Dong, Jing-fei
贡献者: 化學系
关键词: Sepsis;ADAMTS-13;ULWF;Thrombotic microangiopathy
日期: 2007
上传时间: 2012-07-03T03:29:46Z
出版者: Ferrata Storti Foundation
摘要: We studied the state of ultralarge von Willebrand factor (ULVWF) proteolysis in 21
pediatric patients with severe sepsis and found that the overall group of patients
had moderately reduced ADAMTS-13 activity, but 31% had severe enzymatic deficiency.
The severe deficiency correlated with greater adhesion activity of von
Willebrand factor, severity of thrombocytopenia and plasma levels of interleukin-6.
It also correlated clinically with severity of illness and organ dysfunction. These
results suggest that ULVWF proteolysis is insufficient in septic patients and severely
deficient in a subgroup of patients. The deficiency may contribute to the development
of thrombocytopenia and ischemic organ failure associated with sepsis.
關聯: Haematologica, 92(1): 121-124
显示于类别:[化學系] 期刊論文

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