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Please use this identifier to cite or link to this item: http://ir.ncue.edu.tw/ir/handle/987654321/12226

Title: Serotonergic Regulation of Crustacean Hyperglycemic Hormone Secretion in the Crayfish, Procambarus Clarkii
Authors: Lee, Chi-Ying;Yang, Pei-Fen;Zou, Hong-Shin
Contributors: 生物學系
Date: 2001
Issue Date: 2012-07-03T04:02:40Z
Publisher: The University of Chicago
Abstract: These studies investigate if crustacean hyperglycemic hormone
(CHH) is involved in 5-hydroxytryptamine (5-HT)-induced
hyperglycemia. Eyestalk ganglia with intact X-organ–sinus
gland complex were dissected from the crayfish Procambarus
clarkii and incubated under various experimental conditions.
Incubation media were then analyzed for the presence of released
hyperglycemic factor using an in vivo bioassay. The results
show that 5-HT enhanced release of hyperglycemic factor
in a dose-dependent manner. This stimulatory effect of 5-HT
was significantly decreased by adding ketanserin or methysergide
(both 5-HT receptor antagonists) into incubation of eyestalk
ganglia. Further, activity of the 5-HT-released hyperglycemic
factor could be eliminated by adsorption of incubation
media with anti-CHH serum but not by preimmune or anti-
5-HT serum. These results confirm the hypothesis that 5-HT
enhances release of CHH, which in turn elicits hyperglycemic
responses. It is probable that 5-HT activates an excitationsecretion
coupling mechanism by interacting with receptors
located on the X-organ neurosecretory cells.
Relation: Physiological and Biochemical Zoology, 74(3): 376-382
Appears in Collections:[生物學系] 期刊論文

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