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题名: 甲殼類升血糖荷爾蒙等型分泌與血糖濃度之胺性神經調節
Aminergic Regulation of Release of Crustacean Hyperglycemic Hormone Isoforms and Blood Glucose Level
作者: 李奇英
贡献者: 生物系
关键词: Crustacean;Hyperglycemic;Hormone;Polymorphism;Serotonin;Dopamine
日期: 2000
上传时间: 2012-07-03T04:02:46Z
出版者: 行政院國家科學委員會
摘要: Injection of dopamine into Procambarus clarkii resulted in significant hyperglycemic responses. Injection of A77636(a D1 receptor agonist)or quinpirole(a D2 receptor agonist)also elicited significant hyperglycemic responses. Receptor antagonists were used to determine if these drugs were capable of blocking agonist-induced hyperglycemia. SCH23390(a D1 receptor agonist)was unable to block A77636-evoked hyperglycemia, whereas eticlopride(a D2 receptor agonist)partly blocked the dopamine- or quinpirole-evoked hyperglycemia. Furthermore, pretreating the animals with eticlopride did not block the hyperglycemic effect of serotonin(5-HT), an amine neuroregulator also known to elicit hyperglycemic responses. Likewise, pretreating the animals with ketanserin or methysergide (both 5-HT receptor antagonist able to block 5-HT-inuced hyperglycemia or CHH release)did not block the hyperglycemic effect of dopamine significantly increased hemolymph CHH levels. The combined results suggest that 1) dopamine is a potent hyperglycemic factor that increases the glucose levels, at least partly, by enhancing CHH release, 2) hyperglycemic effect of dopamine is mediated by D1- and D2-like receptors that are distantly related to vertebrate counterparts, and 3) 5-HTergic and dopaminergic are independent pathways in regulating glucose levels in Procambarus clarkii.
關聯: 國科會計畫, 計畫編號: NSC89-2311-B018-001; 研究期間: 8808-8907
显示于类别:[生物學系] 國科會計畫


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