In this research, a new electro-encephalogram measurement technique isdesigned and constructed. The structure of virtual instrument built by softwarepart, Lab-viewBhardware part, DAQ card and some external circuits are applied inthe development process. This research integrates different fields that includephysiological signals, circuits, virtual instrument, and physiology. Practicalmeasurements have been carried out to demonstrate the capabilities of this newmeasurement technique.