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http://ir.ncue.edu.tw/ir/handle/987654321/13207
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| Title: | Protective Effect of Extracts of Mesona Procumbens Hemsl. On DNA Damage in Human Lymphocytes Exposed to Hydrogen Peroxide and UV Irradiation |
| Authors: | Yen, G. C.;Hung, Y. L.;Hsieh, Chiu-Lan |
| Contributors: | 生物技術研究所 |
| Keywords: | Mesona procumbens;Lymphocytes;H2O2;UV;DNA damage;Comet assay |
| Date: | 2000-09
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| Issue Date: | 2012-08-07T06:56:36Z
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| Publisher: | Elsevier |
| Abstract: | In the present study, the protective effect of water extracts from Hsian-tsao (WEHT) on DNA damage in human lymphocytes induced by UV-C and/or H(2)O(2) was evaluated using single-cell electrophoresis (comet assay). No toxicity was found in WEHT towards human lymphocytes. WEHT did not cause DNA damage at lower concentrations of 0.05 and 0.1 mg/ml, while it did cause slight DNA damage at a concentration of 0.5-2.5 mg/ml when compared with the control group. When WEHT was mixed with H(2)O(2) for reaction, it exhibited a slight inhibitory effect on DNA damage induced by H(2)O(2). Moreover, when WEHT and lymphocytes were irradiated by UV-C and then incubated for 35 min, the DNA damage decreased with an increase of the concentration of WEHT. Thus, WEHT could reduce UV-C-induced DNA damage, and WEHT had a more protective effect on UV-C than on H(2)O(2)-induced DNA damage. The protective effect of WEHT on DNA damage might be due to the fact that it contains polyphenol compounds and/or other active components. |
| Relation: | Food and Chemical Toxicology, 38(9): 747-754 |
| Appears in Collections: | [生物技術研究所] 期刊論文
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