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| 題名: | Inhibitory Effects of Du-zhong (Eucommia ulmoides Oliv.) Against Low-density Lipoprotein Oxidative Modification |
| 作者: | Yen, Gow-Chin;Hsieh, Chiu-Lan |
| 貢獻者: | 生物技術研究所 |
| 關鍵詞: | Eucommia ulmoides Oliv.;Low-density lipoprotein;Protocatechuic acid |
| 日期: | 2002-06
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| 上傳時間: | 2012-08-07T06:56:40Z
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| 出版者: | Elsevier |
| 摘要: | This study presents the effects of water extracts from leaves, raw cortex, and roasted cortex of Du-zhong (Eucommia ulmoides Oliv.) on the oxidative modification of human low-density lipoprotein (LDL) induced by copper ion (Cu2+). Through determination of the formation of thiobarbituric acid-reactive substances (TBARS) and conjugated dienes (CD), as well as relative electrophoretic mobility (REM), all extracts of Du-zhong were found to possess inhibitory effects on the oxidative modification of LDL induced by Cu2+. The leaf extract had the most significant inhibitory effect. The ethyl acetate extract from leaf extract of Du-zhong was separated into six bands by preparative TLC. Band 2 (Rf=0.40), which was most inhibitory against LDL oxidative modification, was analyzed by HPLC; a single, main peak was collected and further examined using NMR and MS. The antioxidant compound thus identified was protocatechuic acid (PCA). At a concentration of 10 μg/ml, PCA showed a stronger inhibitory effect against LDL oxidative modification induced by Cu2+ than did Du-zhong extracts or ascorbic acid at the same concentration. The results suggest that, in leaf extract of Du-zhong, PCA could be a major source of the inhibitory effect against LDL oxidative modification induced by Cu2+. |
| 關聯: | Food Chemistry, 77(4): 449-456 |
| 顯示於類別: | [生物技術研究所] 期刊論文
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