National Changhua University of Education Institutional Repository : Item 987654321/13212
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 6507/11669
造访人次 : 30013149      在线人数 : 334
RC Version 3.2 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 进阶搜寻

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.ncue.edu.tw/ir/handle/987654321/13212

题名: Antioxidant Activities of Phenolic Acids on Ultraviolet Radiation-Induced Erythrocyte and Low Density Lipoprotein Oxidation
作者: Hsieh, Chiu-Lan;Yen, Gow-Chin;Chen, Hui-Yin
贡献者: 生物技術研究所
关键词: Ultraviolet B;Human erythrocytes;Low-density lipoprotein;Phenolic acids
日期: 2005-07
上传时间: 2012-08-07T06:56:44Z
出版者: American Chemical Society
摘要: The exposure of mammalian cells to UV light induces various deleterious responses. Some of the major harmful effects are DNA damage, cell membrane peroxidation, systemic immune suppression, and aging acceleration. Reactive oxygen species and free radicals are believed to be largely responsible for some of the deleterious effects of UV upon cells. Typical administration of antioxidants has recently proved to represent a successful strategy for protecting the cells against UV-mediated oxidative damage. The objective of this study was to investigate the inhibitory effect of phenolic acids (caffeic acid, ferulic acid, gallic acid, and protocatechuic acid) on oxidative damage in human erythrocytes and low-density lipoprotein (LDL) induced by UVB radiation. The results revealed that the thiobarbituric acids reactive substances induced by UVB were decreased from 2.78 to 0.12−0.89 nmol MDA/mg protein in erythrocyte ghost and from 0.72 to 0.14−0.43 nmol MDA/mg protein in LDL by the addition of phenolic acids (100 μM). Caffeic acid, ferulic acid, and gallic acid exhibited over 85 and 60% inhibitory effect toward UVB-induced oxidation in erythrocytes and LDL, respectively. Phenolic acids, especially gallic acid, could maintain the normal glutathione levels and glutathione peroxidase activity in hemolysate from erythrocytes that were exposed to UVB radiation in comparison with untreated control. The results indicate that the antioxidant activities of caffeic acid and ferulic acid play a potential role in protection against UVB oxidative damage to human erythrocytes and LDL.
關聯: Journal of Agricultural and Food Chemistry, 53(15): 6151-6155
显示于类别:[生物技術研究所] 期刊論文

文件中的档案:

档案 大小格式浏览次数
index.html0KbHTML773检视/开启


在NCUEIR中所有的数据项都受到原著作权保护.

 

DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈