資料載入中.....
|
請使用永久網址來引用或連結此文件:
http://ir.ncue.edu.tw/ir/handle/987654321/13214
|
題名: | Antiandrogenic Therapy Can Cause Coronary Arterial Disease |
作者: | CHEN, KUAN-CHOU;PENG, CHIUNG-CHI;HSIEH, HSIU-MEI;PENG, CHIUNG-HUEI;Hsieh, Chiu-Lan;HUANG, CHIEN-NING;CHYAU, CHARNG-CHERNG;WANG, HUI-ER;PENG, ROBERT Y. |
貢獻者: | 生物技術研究所 |
關鍵詞: | Antiandrogen;CAD (coronary arterial disease);CPA (cyproterone acetate);Hormonal therapy;Prostate cancer |
日期: | 2005-10
|
上傳時間: | 2012-08-07T06:56:49Z
|
出版者: | John Wiley & Sons, Inc. |
摘要: | Aim : To study the change of lipid metabolism by antiandrogen therapy in patients with prostate cancer. Materials and methods : We studied with a 2.5 years follow-up the changes in plasma cholesterols (C), triglycerides (TG), lipoproteins (LP), and apolipoproteins (Apo) B-100, A-I, and A-II profiles in 24 patients of mean age 60 years with low risk prostate cancer (stage: T1cN 0 M 0 , Gleason score: 2–5) during treatment with cyproterone acetate (CPA) without surgical management or radiation therapy. Results : Significant decreases of HDL-C, Apo A-I and Apo A-II and an increase of triglyceride levels in VLDL were induced by CPA. After a period of 2.5 years on CPA treatment, four patients out of twenty-four were found to be affected by coronary heart disease. Conclusions : Ischaemic coronary arteriosclerosis with an incidence rate of 16.6% as caused by prolonged CPA therapy is mediated through changes in HDL cholesterol, Apo A-I and Apo A-II profiles, other than the well-known hyperglyceridemic effect caused by estrogen. |
關聯: | International Journal of Urology 12(10): 886-891 |
顯示於類別: | [生物技術研究所] 期刊論文
|
文件中的檔案:
檔案 |
大小 | 格式 | 瀏覽次數 |
index.html | 0Kb | HTML | 846 | 檢視/開啟 |
|
在NCUEIR中所有的資料項目都受到原著作權保護.
|