National Changhua University of Education Institutional Repository : Item 987654321/13214
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题名: Antiandrogenic Therapy Can Cause Coronary Arterial Disease
作者: CHEN, KUAN-CHOU;PENG, CHIUNG-CHI;HSIEH, HSIU-MEI;PENG, CHIUNG-HUEI;Hsieh, Chiu-Lan;HUANG, CHIEN-NING;CHYAU, CHARNG-CHERNG;WANG, HUI-ER;PENG, ROBERT Y.
贡献者: 生物技術研究所
关键词: Antiandrogen;CAD (coronary arterial disease);CPA (cyproterone acetate);Hormonal therapy;Prostate cancer
日期: 2005-10
上传时间: 2012-08-07T06:56:49Z
出版者: John Wiley & Sons, Inc.
摘要: Aim
: To study the change of lipid metabolism by antiandrogen therapy in patients with prostate
cancer.
Materials and methods
: We studied with a 2.5 years follow-up the changes in plasma cholesterols
(C), triglycerides (TG), lipoproteins (LP), and apolipoproteins (Apo) B-100, A-I, and A-II profiles
in 24 patients of mean age 60 years with low risk prostate cancer (stage: T1cN
0
M
0
, Gleason score:
2–5) during treatment with cyproterone acetate (CPA) without surgical management or radiation
therapy.
Results
: Significant decreases of HDL-C, Apo A-I and Apo A-II and an increase of triglyceride levels
in VLDL were induced by CPA. After a period of 2.5 years on CPA treatment, four patients out of
twenty-four were found to be affected by coronary heart disease.
Conclusions
: Ischaemic coronary arteriosclerosis with an incidence rate of 16.6% as caused by
prolonged CPA therapy is mediated through changes in HDL cholesterol, Apo A-I and Apo A-II
profiles, other than the well-known hyperglyceridemic effect caused by estrogen.
關聯: International Journal of Urology 12(10): 886-891
显示于类别:[生物技術研究所] 期刊論文

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