English  |  正體中文  |  简体中文  |  Items with full text/Total items : 6498/11670
Visitors : 27732544      Online Users : 150
RC Version 3.2 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Adv. Search
Login ‧ Upload ‧ Help ‧ About ‧ Administer

Please use this identifier to cite or link to this item: http://ir.ncue.edu.tw/ir/handle/987654321/13215

Title: Inhibitory Effect of Some Selected Nutraceutic Herbs on LDL Glycation Induced by Glucose and Glyoxal
Authors: Hsieh, Chiu-Lan;Lin, Yuh-Charn;Ko, Wang-Sheng;Peng, Chiung-Hui;Huang, Chien-Ning;Peng, Robert Y.
Contributors: 生物技術研究所
Keywords: Psidium guajava L.;Toona sinensis Roem.;Momordica charantia L.;Graptopetalum paragugayene E. Walther;LDL;Glycation;Glucose;Glyoxal
Date: 2005-12
Issue Date: 2012-08-07T06:56:50Z
Publisher: Elsevier
Abstract: Anti-LDL glycative agents were investigated using aqueous extracts of Psidium guajava L. (PE), Toona sinensis Roem. (TE), Momordica charantia L. (ME) and Graptopetalum paragugayene E. Walther (GE). Concentrations of extracts 0.01–0.625 mg/mL, low density lipoprotein (LDL; 100 μg protein/mL) and inducers glucose (400 mM) and glyoxal (2.5 mM) were incubated at 37 °C. Evaluation parameters involved the thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD), relative electrophoretic mobility (REM), 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging capability and total polyphenolic content. Results for anti-TBARS efficiency (in%) were PE (75.77), TE (75.10), ME (68.81) and GE (19.81) at 0.5 mg/mL, respectively, when induced by glucose; 36.68, 35.60, 32.62 and inactive, respectively, by glyoxal. The lag times for CD formation (in min) were: 289 and 125 by PE and TE, respectively, comparing to the control (45). REM was 1.6 with respect to PE (0.1 mg/mL) compared to the control (4.2). PE at 0.01 mg/mL effectively inhibited with 63.45% efficiency on AGEs induced by glucose. We conclude that PE virtually is a potent antiglycative agent, which can be of great value in the preventive glycation-associated cardiovascular and neurodegenerative diseases.
Relation: Journal of Ethnopharmacology, 102(3): 357-363
Appears in Collections:[生物技術研究所] 期刊論文

Files in This Item:

File SizeFormat
index.html0KbHTML626View/Open


All items in NCUEIR are protected by copyright, with all rights reserved.

 

DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback