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http://ir.ncue.edu.tw/ir/handle/987654321/13223
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| Title: | Kinetic Analysis on the Sensitivity of Glucose- or Glyoxal-induced LDL Glycation to the Inhibitory Effect of Psidium Guajava Extract in a Physiomimic System |
| Authors: | Hsieh, Chiu-Lan;Yang, Ming-Hua;Chyau, Charng-Cherng;Chiu, Chun-Hon;Wang, Hui-Er;Lin, Yuh-Charn;Chiu, Wen-Ta;Peng, Robert Y. |
| Contributors: | 生物技術研究所 |
| Keywords: | Kinetic analysis;LDL glycation;Glucose;Glyoxal;Psidium guajava L |
| Date: | 2007-03
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| Issue Date: | 2012-08-07T06:57:28Z
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| Publisher: | Elsevier |
| Abstract: | Experimentation with a physiomimic system and kinetic analysis exhibited four distinct reaction phases in LDL glycation despite of the type of inducer: glucose or glyoxal. LDL glycation was more sensitive to a status of hyperglycemia (such as 400 mg glucose/100 mL) as evidenced by the reaction order of 0.53. Glucose reacted intensively in the Initial Phase (reaction period 0–2 h) which was identified to result from a parallel mechanism involving both the direct Schiff's product formation and the auto-oxidative cleavages. In contrast, a physiological level of glyoxal revealed merely a reaction order of only 0.09, implicitly indicating a far less sensitive glycation which can be attributed to a mechanism proceeding simply through a molecular Schiff's reaction. On treatment with Psidium guajava L. aqueous extract (PE) (0.01–0.625 mg/mL), a rather unique and significant inhibitory characteristic on LDL glycation was observed with a dose-dependent manner. We attributed such an effect of PE to its distinct abundance of polyphenolic content (165.61 ± 10.39 mg gallic acid equivalent (GAE)/g). Conclusively, PE is an excellent anti-LDL glycative agent whose potential therapeutic uses can be extended to the prevention of a variety of cardiovascular and neurodegenerative diseases associated with glycations. |
| Relation: | Biosystems, 88(1-2): 92-100 |
| Appears in Collections: | [生物技術研究所] 期刊論文
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