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http://ir.ncue.edu.tw/ir/handle/987654321/13236
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| Title: | Quercetin and Ferulic Acid Aggravate Renal Carcinoma in Long-Term Diabetic Victims |
| Authors: | Hsieh, Chiu-Lan;Peng, Chiung-chi;Cheng, Yu-Ming;Lin, Li-Yun;Ker, Yaw-Bee;Chang, Chi-Huang;Chen, Kuan-Chou;Peng, Robert Y. |
| Contributors: | 生物技術研究所 |
| Keywords: | Quercetin;Renal carcimoma;Streptozotocin;Diabetes mellitus |
| Date: | 2010-08
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| Issue Date: | 2012-08-07T06:58:27Z
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| Publisher: | American Chemical Society |
| Abstract: | Many phytoantioxidants have therapeutic drawbacks due to their potent prooxidant bioactivity. It is hypothesized that phytoantioxidants (PAO) are beneficial only to the early-stage diabetes mellitus (DM) and will become ineffective once renopathy occurs. Gallic acid, rutin, EGCG, ferulic acid (FA), and quercetin were tried on the streptozotocin (STZ)-induced DM rat model for a 28 week experimental period. All of these PAO were shown to be ineffective for hypoglycemic action. The incidence of cataract (50%), injured glomerules, and renal cell carcinoma (RCC) was very common, among which the most severely affected involved the quercetin- and the FA-treated groups. The tumorigenicity of ferulic acid is still unclear. However, for quercetin, this can be attributted to (i) the prooxidant effect, (ii) the insulin−secretagogue bioactivity, and (iii) the competitive and noncompetitive inhibition on the O-methyltransferase to enhance the estradiol-induced tumorigenesis. Conclusively, quercetin and FA are able to aggravate, if not induce, nephrocarcinoma. It is time to reevaluate the tumorigenic detrimental effect of PAO, especially those exhibiting prooxidant bioactivity. |
| Relation: | Journal of Agricultural and Food Chemistry, 58(16): 9273-9280 |
| Appears in Collections: | [生物技術研究所] 期刊論文
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