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http://ir.ncue.edu.tw/ir/handle/987654321/14457
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| 題名: | Estimation of Heritability in Myopic Twin Studies |
| 作者: | Tsai, Miao-Yu;Lin, Luke L-K;Lee, Vicky;Chen, Chien-Jen;Shih, Yung-Feng |
| 貢獻者: | 統計資訊研究所 |
| 關鍵詞: | Environmental effect;Genetic effect;Heritability;Myopia |
| 日期: | 2009
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| 上傳時間: | 2012-10-25T09:03:34Z
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| 出版者: | Japanese Ophthalmological Society |
| 摘要: | Purpose: To examine the genetic and environmental factors for myopia at the family level, as well as
risk factors such as ocular measurements and environmental covariates at the individual level, by analysis
of myopic twin data.
Methods: A myopic twin study was conducted on participants from the 2000 Guinness World Records
for twins in Taiwan. A total of 130 participants comprising 58 twin pairs and 13 siblings were recruited.
The generalized estimating equation approach was used to evaluate the covariate effects. A Bayesian
linear mixed model was then used to estimate the heritability.
Results: Pearson’s intrapairwise correlation coeffi cients for ocular refraction and its components were
higher among monozygotic twins than among dizygotic twins. The signifi cance of sex suggested that
women are more myopic than men. Both axial length and anterior chamber depth were signifi cant factors
associated with myopia. The results also showed that people with higher education levels were more
likely to have a higher degree of myopia. After accounting for genetic and environmental effects and
other covariates, the estimate of heritability of myopia was as high as 0.306.
Conclusions: After adjusting for environmental covariates, heritability still plays a decisive genetic role
in the development of myopia. |
| 關聯: | Japanese Journal of Ophthalmology, 53(6): 615-622 |
| 顯示於類別: | [統計資訊研究所] 期刊論文
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