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题名: Reduction in Arsenic Intake from Water Has Different Impacts on Lung Cancer and Bladder Cancer in An Arseniasis Endemic Area in Taiwan
作者: Su, Che-Chun;Lu, Jia-Ling;Tsai, Kuo-Yang;Lian, Ie-Bin
贡献者: 數學系
关键词: Arsenic exposure;Bladder cancer;Lung cancer;APC model
日期: 2010
上传时间: 2012-12-10T02:29:29Z
出版者: SpringerLink
摘要: Background Excessive arsenic intake has a detrimental
effect on human health, as reflected in an increase in cancer
incidence. In an area on the southwest coast of Taiwan,
arsenic intake from well water since the 1920s had caused
an exceptionally high mortality from cancer. Municipal
water has become available to people living in the arseniasis
endemic area since the early 1970s. This study
explored the impacts of reduction in arsenic intake from
water on lung cancer and bladder cancer in the arseniasis
endemic area in Taiwan.
Methods Chart records of 23,013 patients diagnosed with
bladder cancer and 93,633 patients with lung cancer from
1979 to 2003 were retrieved from the Taiwan Cancer
Registry Center. We used the age-period-cohort model to
study the changes in the incidence of lung cancer and
bladder cancer in the arseniasis endemic area and the rest
of Taiwan.
Results Three decades after municipal water supply to the
arseniasis and black foot disease endemic area (BFDEA),
we saw a marked decrease in the incidence of both bladder
cancer and lung cancer in the area, especially for those in
the later cohorts. The relative risk (RR) of getting a bladder
cancer for people living in BFDEA when compared with
those in the rest of Taiwan has dropped from 20 for the
early cohorts to 5 for the late cohorts. As to lung cancer,
the RR has decreased from 8 to between 1.5 and 2.
Conclusion Reduction in arsenic intake from water has a
positive impact on the incidence of both lung and bladder
cancer; however, while RR for lung cancer has dropped to
below 2, RR for bladder cancer remained at around 5. The
difference may be because (1) there are other risk factors
beside the well-water intake or (2) bladder cancer may
have longer latency period for excessive arsenic exposure
than lung cancer. More studies are required to understand
the causes behind the difference in RR for these two types
of cancer.
關聯: Cancer Causes and Control, 22(1): 101-108
显示于类别:[數學系] 期刊論文

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