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题名: A Critical Exploration of Blood and Environmental Chromium Concentration Among Oral Cancer Patients in An Oral Cancer Prevalent Area of Taiwan
作者: Chiang, Chi-Ting;Chang, Tsun-Kuo;Hwang, Yaw-Huei;Su, C. C.;Tsaid, K. Y.;Yuan, T. H.;Lian, Ie-Bin
贡献者: 數學系
关键词: Chromium;Whole blood;Environment;Oral cancer;Soil pollution
日期: 2010
上传时间: 2012-12-10T02:29:29Z
出版者: SpringerLink
摘要: The growing incidence of oral cancer (OC)
in Taiwan has become a crucial public health concern.
In particular, Changhua, a county in central Taiwan,
carries persistently high OC incidence rate, with an
alarmingly high male/female ratio of OC incidence.
Previous epidemiological studies had found that the
incidence is spatially correlated with the level of soil
content to certain heavy metals in the central Taiwan
area. Soil and the human body both intake environmental
heavy metals, which can be absorbed through
various ways. The soil metal concentration is an index
of possible environmental exposure to heavy metal,
and the blood metal concentration somewhat reflects
the level of the exposure on the human body. Metallic
carcinogen is likely to generate free radicals and play a
role in many cancers, and many studies had reported
that environmental exposure to heavy metals is an
important risk factor for developing cancer. Studies on
animals showed that chronic intake of chromium (Cr)
could induce OC. This study aims to explore the
association between the Cr concentration in the farm
soil and in the blood of OC patients. We recruited 79
OC patients from Changhua County, with their
lifestyle being adjusted in regression analysis. The
results showed that the Cr concentration in the blood
of OC patients is significantly higher than the background
value, and is positively associated with the Cr
concentration in the soil surrounding their residence
(p-value\0.023). Because Changhua County is only
with moderate prevalence of the known OC habitual
risk factors, an environmental factor related to heavy
metal Cr exposure is suspected. Future investigations
may verify the causal relation between Cr and OC.
關聯: Environmental Geochemistry and Health, 33(5): 469-476
显示于类别:[數學系] 期刊論文

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