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Title: Synthesis of Caffeic Acid Esters as Antioxidants by Esterification via Acyl Chlorides
Authors: Chen, W. K.;Liao, P. H.;Tsai, C. F.;Lee, Yean-Jang
Contributors: 化學系
Keywords: Caffeic acid phenethyl ester;Antioxidant;Esterification
Date: 1999-08
Issue Date: 2012-12-10T02:51:26Z
Publisher: 中國藥學會臺灣省分會
Abstract: As part of our search for new compounds with improved antibiotic, antiviral, anti-inflammatory and tumor growth inhibition activities, we prepared some caffeic acid esters from commercially available caffeic acid. The rapid total synthesis of caffeic acid esters is described. Highlights of the synthesis include esterification with pyridine catalyst and thermal esterification of acyl chlorides and alcohols in nitrobenzene. Several strategies to accomplish this goal are provided. Finally, CAPE (caffeic acid phenylethyl ester) quenched the free radicals as a phenolic antioxidant.
Relation: The Chinese Pharmaceutical Journal, 51(4): 271-278
Appears in Collections:[Department of Chemistry] Periodical Articles

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