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Title: Total Synthesis of Carpacin and its Geometric Isomer as a Cancer Chemopreventer
Authors: Tseng, T. H.;Tsheng, Y. M.;Lee, Yean-Jang;Hsu, H. L.
Contributors: 化學系
Date: 2000-10
Issue Date: 2012-12-10T02:51:37Z
Publisher: 中國化學學會 
Abstract: Carpacin (1a), an antidepressant in Asiatic folk medicine from the Carpano tree, is achieved in which the longest linear sequence is only four steps in over all yield 67% from commercially available Sesamol. The key transformations in the synthesis are the selective palladium-catalyzed coupling reactions of aryl bromide with Grignard reagents. The first preparation of its geometric isomer (1b) is described. Highlights of the synthesis include Pd-catalyzed coupling, selective hydrogenation, and Wittig reactions. Carpacin was examined as a potential inhibitor of carcinogenesis.
Relation: J. Chin. Chem. Soc., 47(5): 1165-1169
Appears in Collections:[化學系] 期刊論文

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