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Please use this identifier to cite or link to this item:
http://ir.ncue.edu.tw/ir/handle/987654321/14950
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| Title: | Total Synthesis of Carpacin and its Geometric Isomer as a Cancer Chemopreventer |
| Authors: | Tseng, T. H.;Tsheng, Y. M.;Lee, Yean-Jang;Hsu, H. L. |
| Contributors: | 化學系 |
| Date: | 2000-10
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| Issue Date: | 2012-12-10T02:51:37Z
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| Publisher: | 中國化學學會 |
| Abstract: | Carpacin (1a), an antidepressant in Asiatic folk medicine from the Carpano tree, is achieved in which the longest linear sequence is only four steps in over all yield 67% from commercially available Sesamol. The key transformations in the synthesis are the selective palladium-catalyzed coupling reactions of aryl bromide with Grignard reagents. The first preparation of its geometric isomer (1b) is described. Highlights of the synthesis include Pd-catalyzed coupling, selective hydrogenation, and Wittig reactions. Carpacin was examined as a potential inhibitor of carcinogenesis. |
| Relation: | J. Chin. Chem. Soc., 47(5): 1165-1169 |
| Appears in Collections: | [化學系] 期刊論文
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