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NCUEIR > College of Science > Department of Chemistry > Periodical Articles > Item 987654321/14957

Please use this identifier to cite or link to this item: http://ir.ncue.edu.tw/ir/handle/987654321/14957

Title:	Regioselective Hydroxylation of 2-hydroxychalcones by Dimethyldioxirane Towards Polymethoxylated Flavonoids
Authors:	Chu, H. W.;Wu, H. T.;Lee, Yean-Jang
Contributors:	化學系
Date:	2004-03
Issue Date:	2012-12-10T02:51:51Z
Publisher:	Elsevier
Abstract:	The flavone nucleus is part of a large number of natural products and medicinal compounds. In this presentation the novel regioselective hydroxylation of hydroxyarenes with DMD is described. The results showed further that flavonoids with 5-hydroxy group were selectively oxyfunctionalized at the para-position C8 carbon atom by DMD. Finally, according to this methodology, the naturally occurring isosinensetin, tangeretin, sinensetin, nobiletin, natsudaidain, gardenin B, 3,3′,4′,5,6,7,8-heptamethoxyflavone, quercetin and its derivatives were synthesized. The novel regioselective hydroxylation of 2-hydroxychalcones with DMD is described. Based upon this methodology, the polymethoxylated flavonoids are synthesized.
Relation:	Tetrahedron, 60(11): 2647-2655
Appears in Collections:	[Department of Chemistry] Periodical Articles

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