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http://ir.ncue.edu.tw/ir/handle/987654321/14958
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| Title: | Total Synthesis of (�)-camphorataimides and (�)-himanimides by NaBH4/Ni(OAc)2 or Zn/AcOH Stereoselective Reduction |
| Authors: | Chang, C. F.;Lai, Z. C.;Lee, Yean-Jang |
| Contributors: | 化學系 |
| Date: | 2008-05
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| Issue Date: | 2012-12-10T02:51:51Z
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| Publisher: | Elsevier |
| Abstract: | Maleic anhydride 1 of Antrodia camphorate, which can be isolated from Chinese herbal medicine, is achieved in which the longest linear sequence is only five steps, in 40% overall yield from commercially available succinic anhydride. The crucial antrodimides 3 and 2 can be readily transformed by the chemoselective reduction with Zn/AcOH and NaBH4/Ni(OAc)2·4H2O to afford the naturally occurring camphorataimides, 4 and 5, in high yields as well, respectively. This synthetic strategy can also be modified to give access to a variety of different maleic acid derivatives, himanimides 6–8. |
| Relation: | Tetrahedron, 64(19): 4347-4353 |
| Appears in Collections: | [化學系] 期刊論文
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