Loading...
|
Please use this identifier to cite or link to this item:
http://ir.ncue.edu.tw/ir/handle/987654321/14959
|
Title: | Total Synthesis of Demethylwedelolactone and Wedelolactone by Cu-mediated/Pd(0)-catalysis and Oxidative-cyclization |
Authors: | Chang, C. F.;Yang, L. Y.;Chang, S. W.;Fang Y. T.;Lee, Yean-Jang |
Contributors: | 化學系 |
Date: | 2008-04
|
Issue Date: | 2012-12-10T02:51:52Z
|
Publisher: | Elsevier |
Abstract: | Hedysarimcoumestan B, which can be isolated from Chinese herbal medicine, is achieved, in which the longest linear sequence is only eight steps, in 50% overall yield from commercially available phloroglucinol. The key transformations in the synthesis are Cu-mediated/Pd(0)-catalysis and I2/pyridine oxidative-cyclization reactions. This synthetic strategy can be applied to give access to the demethylwedelolactone (4) and wedelolactone (5), which were afforded from commercially available phloroglucinol in high 38 and 33% yields, respectively. |
Relation: | Tetrahedron, 64(17): 3661-3666 |
Appears in Collections: | [化學系] 期刊論文
|
Files in This Item:
File |
Size | Format | |
index.html | 0Kb | HTML | 522 | View/Open |
|
All items in NCUEIR are protected by copyright, with all rights reserved.
|