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NCUEIR > College of Science > Department of Chemistry > Periodical Articles > Item 987654321/14959

Please use this identifier to cite or link to this item: http://ir.ncue.edu.tw/ir/handle/987654321/14959

Title:	Total Synthesis of Demethylwedelolactone and Wedelolactone by Cu-mediated/Pd(0)-catalysis and Oxidative-cyclization
Authors:	Chang, C. F.;Yang, L. Y.;Chang, S. W.;Fang Y. T.;Lee, Yean-Jang
Contributors:	化學系
Date:	2008-04
Issue Date:	2012-12-10T02:51:52Z
Publisher:	Elsevier
Abstract:	Hedysarimcoumestan B, which can be isolated from Chinese herbal medicine, is achieved, in which the longest linear sequence is only eight steps, in 50% overall yield from commercially available phloroglucinol. The key transformations in the synthesis are Cu-mediated/Pd(0)-catalysis and I2/pyridine oxidative-cyclization reactions. This synthetic strategy can be applied to give access to the demethylwedelolactone (4) and wedelolactone (5), which were afforded from commercially available phloroglucinol in high 38 and 33% yields, respectively.
Relation:	Tetrahedron, 64(17): 3661-3666
Appears in Collections:	[Department of Chemistry] Periodical Articles

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