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题名: Total Synthesis of Demethylwedelolactone and Wedelolactone by Cu-mediated/Pd(0)-catalysis and Oxidative-cyclization
作者: Chang, C. F.;Yang, L. Y.;Chang, S. W.;Fang Y. T.;Lee, Yean-Jang
贡献者: 化學系
日期: 2008-04
上传时间: 2012-12-10T02:51:52Z
出版者: Elsevier
摘要: Hedysarimcoumestan B, which can be isolated from Chinese herbal medicine, is achieved, in which the longest linear sequence is only eight steps, in 50% overall yield from commercially available phloroglucinol. The key transformations in the synthesis are Cu-mediated/Pd(0)-catalysis and I2/pyridine oxidative-cyclization reactions. This synthetic strategy can be applied to give access to the demethylwedelolactone (4) and wedelolactone (5), which were afforded from commercially available phloroglucinol in high 38 and 33% yields, respectively.
關聯: Tetrahedron, 64(17): 3661-3666
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