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Please use this identifier to cite or link to this item: http://ir.ncue.edu.tw/ir/handle/987654321/14960

Title: The First Total Synthesis of Kynapcin-24 by Palladium Catalysis
Authors: Yang, Ling-Yi;Chang, Chia-Fu;Huang, Yu-Chao;Lee, Yean-Jang;Hu, Chao-Chin;Tseng, Tsui-Hwa
Contributors: 化學系
Date: 2009
Issue Date: 2012-12-10T02:51:52Z
Publisher: Thieme
Abstract: The synthesis of kynapcin-24, which can be isolated from the Korean mushroom Polyozellus multiflex Murr, is achieved in 12% overall yield from commercially available 3,4-dihydroxybenzaldehyde by a route in which the longest linear sequence is only 14 steps. The key transformations in the synthesis are copper-mediated and palladium-catalyzed coupling reactions of the iodide 3-iodo-5,6-diisopropoxy-2-[(tetrahydropyran-2-yloxy)methyl]benzofuran with the corresponding stannane 5,6-diisopropoxy-2-[(tetrahydropyran-2-yloxy)methyl]-3-(tributylstannyl)benzofuran, and a 5-endo-dig iodocyclization of a (hydroxyphenyl)propargyl ether.
Relation: Synthesis, 7: 1175-1179
Appears in Collections:[化學系] 期刊論文

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