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http://ir.ncue.edu.tw/ir/handle/987654321/14960
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題名: | The First Total Synthesis of Kynapcin-24 by Palladium Catalysis |
作者: | Yang, Ling-Yi;Chang, Chia-Fu;Huang, Yu-Chao;Lee, Yean-Jang;Hu, Chao-Chin;Tseng, Tsui-Hwa |
貢獻者: | 化學系 |
日期: | 2009
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上傳時間: | 2012-12-10T02:51:52Z
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出版者: | Thieme |
摘要: | The synthesis of kynapcin-24, which can be isolated from the Korean mushroom Polyozellus multiflex Murr, is achieved in 12% overall yield from commercially available 3,4-dihydroxybenzaldehyde by a route in which the longest linear sequence is only 14 steps. The key transformations in the synthesis are copper-mediated and palladium-catalyzed coupling reactions of the iodide 3-iodo-5,6-diisopropoxy-2-[(tetrahydropyran-2-yloxy)methyl]benzofuran with the corresponding stannane 5,6-diisopropoxy-2-[(tetrahydropyran-2-yloxy)methyl]-3-(tributylstannyl)benzofuran, and a 5-endo-dig iodocyclization of a (hydroxyphenyl)propargyl ether. |
關聯: | Synthesis, 7: 1175-1179 |
顯示於類別: | [化學系] 期刊論文
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