National Changhua University of Education Institutional Repository : Item 987654321/14960

English | 正體中文 | 简体中文 | Items with full text/Total items : 6507/11669
Visitors : 30053218 Online Users : 577

RC Version 3.2 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.

Scope Adv. Search

Login ‧ Upload ‧ Help ‧ About ‧ Administer

NCUEIR > College of Science > Department of Chemistry > Periodical Articles > Item 987654321/14960

Please use this identifier to cite or link to this item: http://ir.ncue.edu.tw/ir/handle/987654321/14960

Title:	The First Total Synthesis of Kynapcin-24 by Palladium Catalysis
Authors:	Yang, Ling-Yi;Chang, Chia-Fu;Huang, Yu-Chao;Lee, Yean-Jang;Hu, Chao-Chin;Tseng, Tsui-Hwa
Contributors:	化學系
Date:	2009
Issue Date:	2012-12-10T02:51:52Z
Publisher:	Thieme
Abstract:	The synthesis of kynapcin-24, which can be isolated from the Korean mushroom Polyozellus multiflex Murr, is achieved in 12% overall yield from commercially available 3,4-dihydroxybenzaldehyde by a route in which the longest linear sequence is only 14 steps. The key transformations in the synthesis are copper-mediated and palladium-catalyzed coupling reactions of the iodide 3-iodo-5,6-diisopropoxy-2-[(tetrahydropyran-2-yloxy)methyl]benzofuran with the corresponding stannane 5,6-diisopropoxy-2-[(tetrahydropyran-2-yloxy)methyl]-3-(tributylstannyl)benzofuran, and a 5-endo-dig iodocyclization of a (hydroxyphenyl)propargyl ether.
Relation:	Synthesis, 7: 1175-1179
Appears in Collections:	[Department of Chemistry] Periodical Articles

Files in This Item:

File	Size	Format
2020400210020.pdf	6Kb	Adobe PDF	736	View/Open