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NCUEIR > College of Science > Department of Chemistry > Periodical Articles > Item 987654321/1553

Please use this identifier to cite or link to this item: http://ir.ncue.edu.tw/ir/handle/987654321/1553

Title:	Aptamer-modified gold nanoparticles for targeting breast cancer cells through light scattering
Authors:	Huang, Y.-F.;Lin, Y.-W.;Lin, Z. -H.;Chang, H.-T.
Contributors:	化學系
Keywords:	Aptamer Gold nanoparticles Breast cancer cells Imaging Proliferation Nanomedicine
Date:	2009
Issue Date:	2010-11-10T06:50:11Z
Abstract:	In this study, we demonstrated the potential use of nucleic acid ligand (aptamers) conjugated gold nanoparticles (AuNPs) for cancer cell detection. Through specific binding of the aptamers toward platelet-derived growth factor (PDGF), MDA-MB-231 and Hs578T cells (cancer cells) that over-express PDGF, interact with Apt-AuNPs to a greater extent than do H184B5F5/M10 cells (normal cells). These results were confirmed through inductively coupled plasma mass spectrometry measurements of the gold ion concentrations within these cells. Aggregation of the Apt-AuNPs in the cytoplasm of the cancer cells led to the generation of an intense scattered light upon photo-illumination; this phenomenon allows the differentiation of cancer cells from normal cells using a dark field optical microscope. The presence of Apt-AuNPs suppressed the proliferation of MDA-MB-231 cancer cells, but not H184B5F5/M10 cells.
Relation:	J. Nano. Res., 11, 775-783
Appears in Collections:	[Department of Chemistry] Periodical Articles

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