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NCUEIR > College of Science > Department of Chemistry > Periodical Articles > Item 987654321/1558

Please use this identifier to cite or link to this item: http://ir.ncue.edu.tw/ir/handle/987654321/1558

Title:	Nanomaterial-Based Surface-Assisted Laser Desorption/Ionization Mass Spectrometry of Peptides and Proteins
Authors:	Chiang, C.-K.;Chiang, N.-C.;Lin, Z.-H.;Lan, G.-Y.;Lin, Y.-W.;Chang, H.-T.
Contributors:	化學系
Date:	2010
Issue Date:	2010-11-10T06:54:41Z
Abstract:	We have investigated six nanomaterials for their applicability as surfaces for the analyses of peptides and proteins using surface-assisted laser desorption/ionization mass spectrometry(SALDI-MS). Gold nanoparticles (NPs) were useful nanomaterials for small analytes (e.g., glutathione); Pt nanosponges and Fe3O4 NPs were efficient nanomaterials for proteins, with an upper detectable mass limit of ca. 25 kDa. Nanomaterials have several advantages over organic matrices, including lower limits of detection for small analytes and lower batch-to-batch variations (fewer problems associated with “sweet spots”), when used in laser desorption/ionization mass spectrometry. (J Am Soc Mass Spectrom 2010, 21, 1204–1207) © 2010 American Society for Mass Spectrometry.
Relation:	J. Am. Soc. Mass Spectrom. 21, 1204–1207
Appears in Collections:	[Department of Chemistry] Periodical Articles

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