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|Title: ||Quantification of Captopril in Urine Through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Using 4-Mercaptobenzoic Acid–Capped Gold Nanoparticles as an Internal Standard|
|Authors: ||Chen, W.-T.;Chiang, C.-K.;Lin, Y.-W.;Chang, H.-T.|
|Issue Date: ||2010-11-10T06:55:50Z
|Abstract: ||We have developed a new internal standard method for the determination of the concentration of captopril (CAP) through surface-assisted laser desorption/ionization mass spectrometry (SALDIMS) using gold nanoparticles (Au NPs). This approach provided linearity for CAP over the concentration range 2.5–25 M (R2 0.987), with a limit of detection (signal-to-noise ratio 3) of 1.0 M. The spot-to-spot variations in the concentration of CAP through SALDI-MS analyses performed in the absence and presence of the internal standard were 26% and 9%, respectively (15 measurements). This approach provides simplicity, accuracy, precision, and great reproducibility to the determination of the levels of CAP in human urine samples. (J Am Soc Mass Spectrom
2010, 21, 864–867) © 2010 American Society for Mass Spectrometry.
|Relation: ||J. Am. Soc. Mass Spectrom. 21, 864–867|
|Appears in Collections:||[化學系] 期刊論文|
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