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题名: Exploring the Interactions between Gold Nanoparticles and Analytes through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry
作者: Lin, Y.-W.;Chen, W.-T.;Chang, H.-T.
贡献者: 化學系
日期: 2010
上传时间: 2010-11-10T06:58:38Z
摘要: Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is applied to provide strong evidence for the chemical reactions of functionalized gold nanoparticles (Au NPs) with
analytes – Hg2R ions induced MPA Au NPs aggregation in the presence of 2,6-pyridinedicarboxylic acid (PDCA) and H2O2 induced fluorescence quenching of 11-MUA Au NDs. PDCA-Hg2R-MPA coordination is responsible for Au NPs aggregation, while the formation of 11-MUA disulfide
compounds that release into the bulk solution is responsible for H2O2-induced fluorescence quenching. In addition to providing information about the chemical structures, SALDI-MS is also selective and sensitive for the detection of Hg2R ions and H2O2. The limits of detection (LODs) for Hg2R ions and H2O2 by SALDI-MS were 300nM and 250mM, respectively. The spot-to-spot variations in the two studies were both less than 18% (50 sample spots). Our results reveal that SALDI-MS can be used to study analyte-induced changes in the surface properties of nanoparticles.
關聯: Rapid Commun. Mass Spectrom., 24, 933-938
显示于类别:[化學系] 期刊論文





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