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题名: Curcumin Affects Development of Zebrafish Embryo
作者: Wu, Jheng-Yu;Lin, Chin-Yi;Lin, Tien-Wei;Ken, Chuian-Fu;Wen, Yu-Der
贡献者: 生物學系
关键词: Curcumin;Embryotoxicity;Zebrafish
日期: 2007
上传时间: 2013-06-05T08:48:17Z
出版者: Pharmaceutical Society of Japan
摘要: Embryotoxic and teratogenic effects of curcumin on the development of zebrafish embryo were investi-gated in this study. The LD50 values of curcumin (24-h incubation) were estimated at 7.5 μM and 5 μM for embryos and larvae, respectively. The developmental defects caused by curcumin treatments include bent or hook-like tails, spinal column curving, edema in pericardial sac, retarded yolk sac resorption, and shorter body length. In curcumin-treated larvae, fluorescence signals of curcumin were found in edamae sac and some skin cells. Together, these results indicate that zebrafish are suitable model organisms to study the toxic effects of curcumin.
關聯: Biological & Pharmaceutical Bulletin, 30(7): 1336-1339
显示于类别:[生物學系] 期刊論文


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