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Please use this identifier to cite or link to this item: http://ir.ncue.edu.tw/ir/handle/987654321/18904

Title: Heme Cleavage with Remarkable Ease: Paramagnetic Intermediates Formed by Aerobic Oxidation of a Meso-Amino-Substituted Iron Porphyrin
Authors: Heather Kalish;Lee, Hon Man;Marilyn M. Olmstead;Lechosław Latos-Grazù yn´ ski;Sankar Prasad Rath;Alan L. Balch
Contributors: 化學系
Date: 2003-04
Issue Date: 2014-08-14T04:28:51Z
Publisher: American Chemical Society
Abstract: Hemes must be oxidatively stable to carry out their functions as biological oxidants, but introduction of a single amino group at a meso position of octaethylheme renders it extremely sensitive to ring opening by dioxygen. Exposure of a red pyridine (py) solution of diamagnetic (py)2FeII(H2N-OEP) (1) (H2N-OEP is the dianion of meso-amino-octaethylporphyrin) to air results in the immediate formation of a green intermediate which is subsequently converted into a second species that has been crystallized and characterized by X-ray diffraction. This process is distinct from coupled oxidation, a model for biological heme cleavage, because it does not require a sacrificial reducing agent to initiate the process.
Relation: Journal of the American Chemical Society, 125(16): 4674-4675
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