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Please use this identifier to cite or link to this item: http://ir.ncue.edu.tw/ir/handle/987654321/8990

Title: Epigenetic Stratification: The Role of Individual Change in the Biological Aging Process
Authors: S.Michal Jazwinski;Sangkyu Kim;Chi-Yung Lai;Alberto Benguria
Contributors: 生物系
Keywords: aging;longevity;mortality rate;cell polarity;silencing;nonlinear systems
Date: 1998-09
Issue Date: 2011-05-16T07:39:32Z
Publisher: Elsevier Science
Abstract: Aging is a complex process. It consists of a diverse assortment of seemingly random manifestations that occur in the individual, the mutual relationship and impact on mortality of which is frequently obscure. We derive a simple equation to model the aging process based on scale invariant and increasing change. The solution to this equation indicates that this change itself, irrespective of its quality, is the cause and not simply the effect of aging. This model establishes loss of homeostasis as a fundamental feature of aging. The model is deterministic, but it supports the stochastic nature of age changes. Paradoxically, this model states that a sufficient augmentation of aging processes results in a lack of aging. Experimental evidence in support of this model is presented that spans the levels of population mortality rates, cellular spatial organization, and gene dysregulation.
Relation: Experimental Gerontology, 33(6):571-580
Appears in Collections:[生物技術研究所] 期刊論文

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