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题名: Epigenetic Stratification: The Role of Individual Change in the Biological Aging Process
作者: S.Michal Jazwinski;Sangkyu Kim;Chi-Yung Lai;Alberto Benguria
贡献者: 生物系
关键词: aging;longevity;mortality rate;cell polarity;silencing;nonlinear systems
日期: 1998-09
上传时间: 2011-05-16T07:39:32Z
出版者: Elsevier Science
摘要: Aging is a complex process. It consists of a diverse assortment of seemingly random manifestations that occur in the individual, the mutual relationship and impact on mortality of which is frequently obscure. We derive a simple equation to model the aging process based on scale invariant and increasing change. The solution to this equation indicates that this change itself, irrespective of its quality, is the cause and not simply the effect of aging. This model establishes loss of homeostasis as a fundamental feature of aging. The model is deterministic, but it supports the stochastic nature of age changes. Paradoxically, this model states that a sufficient augmentation of aging processes results in a lack of aging. Experimental evidence in support of this model is presented that spans the levels of population mortality rates, cellular spatial organization, and gene dysregulation.
關聯: Experimental Gerontology, 33(6):571-580
显示于类别:[生物技術研究所] 期刊論文


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