National Changhua University of Education Institutional Repository : Item 987654321/8991
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题名: Interorganelle Signaling is a Determinant of Longevity in Saccharomyces Cerevisiae
作者: Kirchman, P.A.;S. Kim;C.Y. Lai;S.M. Jazwinski
贡献者: 生物系
日期: 1999-05
上传时间: 2011-05-16T07:39:43Z
出版者: Genetics Society of America
摘要: Replicative capacity, which is the number of times an individual cell divides, is the measure of longevity in the yeast Saccharomyces cerevisiae. In this study, a process that involves signaling from the mitochondrion to the nucleus, called retrograde regulation, is shown to determine yeast longevity, and its induction resulted in postponed senescence. Activation of retrograde regulation, by genetic and environmental means, correlated with increased replicative capacity in four different S. cerevisiae strains. Deletion of a gene required for the retrograde response, RTG2, eliminated the increased replicative capacity. RAS2, a gene previously shown to influence longevity in yeast, interacts with retrograde regulation in setting yeast longevity. The molecular mechanism of aging elucidated here parallels the results of genetic studies of aging in nematodes and fruit flies, as well as the caloric restriction paradigm in mammals, and it underscores the importance of metabolic regulation in aging, suggesting a general applicability.
關聯: Genetics, 152(1):179-190
显示于类别:[生物技術研究所] 期刊論文

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