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題名: A Novel Role of Peroxin Pex6: Suppression of Aging Defects in Mitochondria
作者: Seo, J. G.;C. Y. Lai;M. V. Miceli;S. M. Jazwinski
貢獻者: 生物系
關鍵詞: Age asymmetry;Aging;Metabolism;Peroxisomes;Stem cells
日期: 2007-06
上傳時間: 2011-05-16T07:39:48Z
出版者: Wiley-Blackwell
摘要: Yeast cells become older with each division, but their daughters are born young. Mutational analysis shows that maintenance of this age asymmetry requires segregation of a complement of active mitochondria to daughters and that this process breaks down in older mother cells. This decline has implications for stem cell aging in higher organisms. PEX6, a peroxisome biogenesis gene, has been isolated as a multicopy suppressor of an atp2 age asymmetry mutant. Suppression depended on the presence of particular amino acid residues in Atp2p, and required adenosine triphosphate (ATP) binding and/or ATP hydrolysis activity of Pex6p. Extra copies of PEX6 corrected the deficit in Atp2p in mitochondria in the mutant by improving its import kinetics, resulting in near normal mitochondrial inheritance by daughter cells. The novel function of Pex6p described here may provide insights into peroxisomal and mitochondrial disorders and into metabolic diseases in general.
關聯: Aging Cell, 6(3):405-413
顯示於類別:[生物技術研究所] 期刊論文

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