National Changhua University of Education Institutional Repository : Item 987654321/9763

English | 正體中文 | 简体中文 | Items with full text/Total items : 6507/11669
Visitors : 29998709 Online Users : 394

RC Version 3.2 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.

Scope Adv. Search

Login ‧ Upload ‧ Help ‧ About ‧ Administer

NCUEIR > College of Social Science and Physical Education > ss > Periodical Articles > Item 987654321/9763

Please use this identifier to cite or link to this item: http://ir.ncue.edu.tw/ir/handle/987654321/9763

Title:	Effect of Ethanol Extracts of Three Chinese Medicinal Plants with Anti-diarrheal Properties on Ion Transport of the Rat Intestinal Epithelia
Authors:	Tsai, Jong-Chang;Tsai, S.;Chang, W.C.
Contributors:	應用運動科學所
Keywords:	Chinese medicinal plant, ion transport, intestinal epithelia, anti-diarrhea,
Date:	2004-02
Issue Date:	2012-04-20T02:22:33Z
Publisher:	The Japanese Pharmacological Society
Abstract:	Effects of ethanol extracts of three Chinese medicinal plants, namely, Qinpi (Fraxini cortex), Kushen (Sophora flavescens, AITON), and Huanglian (Coptis teeta, WALLICH), on ion transport of the rat intestinal epithelia were determined in this study. Rat intestinal epithelia mounted in an Ussing chamber attached to a voltage/current clamp were used for measuring changes in the short circuit current across the epithelia. Activation of the intestinal epithelia by serosal administration of 5 microM forskolin resulted in an increase in basal short circuit current. The ethanol extracts of each of the three plants partially reduced the current stimulated by forskolin. In the following experiments, ouabain and bumetanide were added prior to adding the ethanol extract of these plants for revealing their effect on Na(+) and Cl(-) movement. The results suggest that the ethanol extract of the Qinpi would affect Cl(-) transport. On the contrary, the ethanol extract of Kushen would affect Na(+) transport rather than Cl(-) movement. This study provides evidences that reveal the pharmacological mechanism of the Chinese plants with anti-diarrheal properties.
Relation:	Journal of Pharmacological Sciences, 94: 60-66
Appears in Collections:	[ss] Periodical Articles

Files in This Item:

File	Size	Format
2070100410003.pdf	248Kb	Adobe PDF	1336	View/Open

Loading...