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|Title: ||Regioselective Hydroxylation of 2-hydroxychalcones by Dimethyldioxirane Towards Polymethoxylated Flavonoids|
|Authors: ||Chu, H. W.;Wu, H. T.;Lee, Yean-Jang|
|Issue Date: ||2012-12-10T02:51:51Z
|Abstract: ||The flavone nucleus is part of a large number of natural products and medicinal compounds. In this presentation the novel regioselective hydroxylation of hydroxyarenes with DMD is described. The results showed further that flavonoids with 5-hydroxy group were selectively oxyfunctionalized at the para-position C8 carbon atom by DMD. Finally, according to this methodology, the naturally occurring isosinensetin, tangeretin, sinensetin, nobiletin, natsudaidain, gardenin B, 3,3′,4′,5,6,7,8-heptamethoxyflavone, quercetin and its derivatives were synthesized.|
The novel regioselective hydroxylation of 2-hydroxychalcones with DMD is described. Based upon this methodology, the polymethoxylated flavonoids are synthesized.
|Relation: ||Tetrahedron, 60(11): 2647-2655|
|Appears in Collections:||[化學系] 期刊論文|
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