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题名: The First Total Synthesis of Kynapcin-24 by Palladium Catalysis
作者: Yang, Ling-Yi;Chang, Chia-Fu;Huang, Yu-Chao;Lee, Yean-Jang;Hu, Chao-Chin;Tseng, Tsui-Hwa
贡献者: 化學系
日期: 2009
上传时间: 2012-12-10T02:51:52Z
出版者: Thieme
摘要: The synthesis of kynapcin-24, which can be isolated from the Korean mushroom Polyozellus multiflex Murr, is achieved in 12% overall yield from commercially available 3,4-dihydroxybenzaldehyde by a route in which the longest linear sequence is only 14 steps. The key transformations in the synthesis are copper-mediated and palladium-catalyzed coupling reactions of the iodide 3-iodo-5,6-diisopropoxy-2-[(tetrahydropyran-2-yloxy)methyl]benzofuran with the corresponding stannane 5,6-diisopropoxy-2-[(tetrahydropyran-2-yloxy)methyl]-3-(tributylstannyl)benzofuran, and a 5-endo-dig iodocyclization of a (hydroxyphenyl)propargyl ether.
關聯: Synthesis, 7: 1175-1179
显示于类别:[化學系] 期刊論文


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