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NCUEIR > College of Science > Department of Biology > Periodical Articles > Item 987654321/16776

Please use this identifier to cite or link to this item: http://ir.ncue.edu.tw/ir/handle/987654321/16776

Title:	Curcumin Affects Development of Zebrafish Embryo
Authors:	Wu, Jheng-Yu;Lin, Chin-Yi;Lin, Tien-Wei;Ken, Chuian-Fu;Wen, Yu-Der
Contributors:	生物學系
Keywords:	Curcumin;Embryotoxicity;Zebrafish
Date:	2007
Issue Date:	2013-06-05T08:48:17Z
Publisher:	Pharmaceutical Society of Japan
Abstract:	Embryotoxic and teratogenic effects of curcumin on the development of zebrafish embryo were investi-gated in this study. The LD50 values of curcumin (24-h incubation) were estimated at 7.5 μM and 5 μM for embryos and larvae, respectively. The developmental defects caused by curcumin treatments include bent or hook-like tails, spinal column curving, edema in pericardial sac, retarded yolk sac resorption, and shorter body length. In curcumin-treated larvae, fluorescence signals of curcumin were found in edamae sac and some skin cells. Together, these results indicate that zebrafish are suitable model organisms to study the toxic effects of curcumin.
Relation:	Biological & Pharmaceutical Bulletin, 30(7): 1336-1339
Appears in Collections:	[Department of Biology] Periodical Articles

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